Chemistry-Based Computer-Assisted Biology-Oriented Studies
~CBCABOS~
Our group is particularly interested in the following aspects: (a) SYNTHETIC METHOD DEVELOPMENT, especially those leading to the foundamental C-X bond formation, or construction of new scaffolds or having applications in the synthesis of natural products and bioactive agents; (b) the construction of high-quality molecular library (e.g. sp3-riched); (c) Identification of NEW ANTICANCER LEADS using the computational (e.g. FBDD, High Throughput Virtual Screening, Structure-Based Drug Design, molecular dynamic modelling, etc) and/or knowledge-based approaches, contemporary drug design strategies (e.g. scaffold hopping, bioisosteric replacement, molecular hybridization, etc), and HTS strategies; (d) Development of ME-TOO/BETTER DRUGS with improved in vivo potency and/or lower toxicity; (e) CANCER BIOLOGY with particular emphasis on the underlying mechanisms of multiple drug resistance.
Part 1: Discovery of new small-molecule inhibitors/degraders targeting epigenetic targets and exploration of their anticancer potentials
Part 2: Design of small-molecule compounds targeting neddylation pathways
Part 3: Construction of small-molecule compound collections
Part 2: Design of small-molecule compounds targeting neddylation pathways
Part 3: Construction of small-molecule compound collections